Market Update Ascendis Health Limited (Registration number 2008/005856/06) (Incorporated in the Republic of South Africa) Share code: ASC ISIN: ZAE000185005 ("Ascendis Health" or "the Company") MARKET UPDATE Shareholders are referred to the announcement published on SENS on 28 October 2021 in which they were informed that Mr H Smit had acquired a beneficial interest in Ascendis Health securities of 30%. The Takeover Regulation Panel ("TRP") has concluded, pursuant to its own investigation, that the information contained in the abovementioned SENS announcement was inaccurate. It found that, sometime in September 2021, Mr Smit and other shareholders of Ascendis Health concluded a voting pool agreement in terms of which these shareholders appointed him as their proxy in respect of their shareholding in Ascendis for a period of six to twenty four months from the date of the conclusion of that agreement. This arrangement between Mr Smit and these shareholders appears to have been the only basis that the purported section 122 Companies Act 2008 ("Act") disclosure by Mr Smit was made. The TRP found that as such Mr Smit did not hold a beneficial interest in the securities of Ascendis Health, totalling 30%, as communicated to the Company by him in his TRP Form 121.1. The TRP has therefore directed the Company to make this announcement in order to correct the announcement that the Company was compelled to make in terms of section 122(3) of the Act, pursuant to the receipt of such TRP Form 121.1. The board of Ascendis Health ("the Board") accepts responsibility for the information contained in this announcement as it pertains to Ascendis Health. To the best of the Board's knowledge and belief, the information contained in this announcement as it pertains to Ascendis Health is true, and nothing has been omitted which is likely to affect the importance of such information. 21 December 2021 Bryanston Sponsor Questco Corporate Advisory Proprietary Limited Date: 21-12-2021 03:40:00 Produced by the JSE SENS Department. The SENS service is an information dissemination service administered by the JSE Limited ('JSE'). The JSE does not, whether expressly, tacitly or implicitly, represent, warrant or in any way guarantee the truth, accuracy or completeness of the information published on SENS. The JSE, their officers, employees and agents accept no liability for (or in respect of) any direct, indirect, incidental or consequential loss or damage of any kind or nature, howsoever arising, from the use of SENS or the use of, or reliance on, information disseminated through SENS.