Renewal of Cautionary Announcement – API Business ASPEN PHARMACARE HOLDINGS LIMITED (Incorporated in the Republic of South Africa) (“Aspen Holdings”) Registration number: 1985/002935/06 Share code: APN ISIN: ZAE000066692 LEI: 635400ZYSN1IRD5QWQ94 and its subsidiaries (collectively “Aspen” or “the Group”) RENEWAL OF CAUTIONARY ANNOUNCEMENT – API BUSINESS Shareholders are referred to the cautionary announcement released by Aspen on 9 September 2021, and its subsequent renewal of 21 October 2021, in which shareholders were advised that Aspen had received two unsolicited offers for its active pharmaceutical ingredient business (“API Business”)(1). This announcement also confirmed that Aspen had decided to embark on a structured process to facilitate offers for all or parts of its API Business from those parties that submitted the unsolicited offers and other selected interested parties. Shareholders are advised that this structured process remains ongoing and may have a material effect on the price of Aspen’s securities if successfully concluded and accordingly shareholders are advised to continue exercising caution when dealing in Aspen’s securities. Footnote: (1) Comprising the Chemicals and Biochem segments of Aspen’s Manufacturing operations, situated in the Netherlands, South Africa and the United States. Durban 03 December 2021 Sponsor Investec Bank Limited Date: 03-12-2021 08:00:00 Produced by the JSE SENS Department. The SENS service is an information dissemination service administered by the JSE Limited ('JSE'). The JSE does not, whether expressly, tacitly or implicitly, represent, warrant or in any way guarantee the truth, accuracy or completeness of the information published on SENS. The JSE, their officers, employees and agents accept no liability for (or in respect of) any direct, indirect, incidental or consequential loss or damage of any kind or nature, howsoever arising, from the use of SENS or the use of, or reliance on, information disseminated through SENS.