Changes in function of directors ASCENDIS HEALTH LIMITED (Incorporated in the Republic of South Africa) (Registration number 2008/005856/06) Share code: ASC ISIN: ZAE000185005 (“Ascendis Health” or “the Company”) CHANGES IN FUNCTION OF DIRECTORS Shareholders are advised that following the appointment of Amaresh Chetty, Bharti Harie and Carl Neethling as directors of Ascendis Health and the resignation of Gary Shayne as a director of Ascendis Health, the committees of the board of directors of Ascendis Health (the “Board”) have been reconstituted to comprise the following members: Audit and risk committee Bharti Harie (chairman), Amaresh Chetty, Karsten Wellner and Lawrence Mulaudzi. Human capital committee Amaresh Chetty (chairman), Bharti Harie, Harry Smit and Carl Neethling. Social, ethics and transformation committee Amaresh Chetty (chairman), Lawrence Mulaudzi, Harry Smit, Bharti Harie and CJ Kujenga. The Board has conducted an evaluation in respect of the independence of the non-executive directors of Ascendis Health. Karsten Wellner, Lawrence Mulaudzi and Carl Neethling have been designated non- independent non-executive directors and Harry Smit, Richard Dawes, Amaresh Chetty and Bharti Harie have been designated independent non-executive directors. The Board accepts responsibility for the information contained in this announcement as it pertains to Ascendis Health. To the best of the Board's knowledge and belief, the information contained in this announcement as it pertains to Ascendis Health is true and nothing has been omitted which is likely to affect the importance of such information. 13 June 2022 Johannesburg Sponsor Questco Corporate Advisory (Pty) Ltd Date: 13-06-2022 12:45:00 Produced by the JSE SENS Department. The SENS service is an information dissemination service administered by the JSE Limited ('JSE'). The JSE does not, whether expressly, tacitly or implicitly, represent, warrant or in any way guarantee the truth, accuracy or completeness of the information published on SENS. The JSE, their officers, employees and agents accept no liability for (or in respect of) any direct, indirect, incidental or consequential loss or damage of any kind or nature, howsoever arising, from the use of SENS or the use of, or reliance on, information disseminated through SENS.